Role of Mediator Complex Subunit 12 Mutation in Fibro-adenoma and Phyllodes Tumour of Breast

Abstract

Objective: To determine the role of mediator complex subunit 12 mutation in fibro-adenoma and phyllodes tumour of breast.

Study Design: Retrospective observational

Place and Duration of Study: This study was conducted at the department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, from January, 2016 to December, 2020.

Materials and Methods: A total of 52 cases of fibro-adenoma and 5 cases of phyllodes tumour of breast were received and evaluated for mediator complex subunit 12 gene mutations by using polymerase chain reaction method. The results were analyzed using SPSS version 22.

Results: Out of 52 cases of fibro-adenoma only 17 (32%) found to be positive in gene mutation whereas 3(60%) cases out of 5 of phyllodes tumour were positive. The phyllodes tumour was divided into benign, borderline and malignant. Cases of borderline and malignant phyllodes tumour could not be retrieved in our study

Conclusion: Present study concludes that MED12 gene exon 2 mutation in fibro-adenomas and benign phyllodes tumors of breast is not substantial.