Pattern of Bone Marrow Infiltration in Hogkin’s Lymphoma

Abstract

Objective: To determine the pattern of bone marrow infiltration in Hogkin’s Lymphoma.

Study Design: Cross-sectional study

Place and Duration of Study: This study was conducted at the Department of Hematology, Nishtar hospital, Multan from October 2021 to September 2022.

Materials and Methods: A total of 145 patients were recruited from hematology department of hospital. Main variables of study were histopathology pattern, duration of diagnosis, gender and age. Bone marrow trephine biopsy was done from posterior superior iliac spine to assess the pattern of bone marrow infiltration. Pattern of bone marrow infiltration was assessed in terms of diffuse, interstitial and focal.

Results: The mean age of the patients was 36.02±6.33 years. The mean duration of diagnosis was 6.55±2.42 months. There were 64.4% patients between 3-6 months of duration of diagnosis and 35.6% between 7-9 months. Major included variables were histopathological pattern, in our study. Out of the 100%, diffuse was noted in 29% patients, interstitial was noted in 62% and focal was noted in 9% patients.

Conclusion: Bone marrow infiltration is a frequent event in Hodgkin's lymphoma and interstitial pattern is more common, and should be taken into consideration when determining the prognosis and treatment plan.