Pterygium Excision and Limbal Conjunctival Autograft with Versus without the use of Mitomycin-C in Patients below the age of 45 Years

Abstract

Objectives: To compare pterygium recurrence following excision with limbal conjunctival autograft with application of Mitomycin-C versus non application of Mitomycin-C in patients below age 45 years. 

Study Design:  Randomized Control Trial.

Place and Duration of Study: This study was conducted at the Department of Ophthalmology, NMC, Multan from 15.06.2009 to 15.12.2009.

Materials and Methods: Total 86 patients with the age range 25-44 years were selected for this study and categorized randomly into two groups, group-I (n=43) and group-II (n=43). Pterygium surgery was performed with limbal conjunctival autograft without the use of Mitomycin-C in group-I and with the use of Mitomycin-C in group-II. Three patients out of 86 cases did not visit for follow-up. 

Results: Pterygium was more prevalent in males (n=65, 75.58%) and majority of the patients (n=36, 41.9%) were between 41-44 years of age. There were 7 (17.07%) cases of recurrence observed in group-I and  only 1 (2.38%)case of  recurrence in group-II, the difference in recurrence rate was statistically significant (p=0.02).

Conclusion: For pterygium surgery, limbal conjunctival autograft combined with intraoperative application of Mitomycin C is recommended.