Lipid Profile in Females of Reproductive Age Group Using Injectable Contraceptives (Progestogen-only)

Abstract

Objective: To determine and compare the values of lipid profile in married fertile females of reproductive age group using injectable contraceptives. 

Study Design: Comparative cross sectional study.

Place and Duration of Study:  This study was carried out in the Department of Biochemistry, Postgraduate Medical Institute, Lahore and Lahore General Hospital, Lahore from July 2010 to Dec 2010.

Materials and Methods: A total of 250 married fertile women in their reproductive age were selected. They were divided in two groups: Group 1 (controls) and Group 2 (injectable contraceptive users). Levels of serum total cholesterol, serum triglycerides, high density lipoprotein-cholesterol were measured using standard kits. Low density lipoprotein-cholesterol was calculated with Fried Wald equation. Results were analyzed by using student’s t test. Informed consent was taken from each patient and control subject for this study.

Results: Injectable contraceptives cause significant decrease in HDL-C and significant increase in serum triglycerides and LDL-C.

Conclusion: It is suggested that Lipid profile should be estimated before starting every course (the course may be 3-6months) of injectable contraceptives to the subjects.