Histopathological Spectrum of Gastric Biopsies in a Tertiary Care Hospital

Abstract

  ABSTRACT

Objective: This study was carried out to determine the histopathological spectrum of gastric lesions at a tertiary care hospital

Study Design: A retrospective study

Descriptive Study: This study was conducted at Dr. Tahir Laboratory from Gastroenterology unit of Hamdard University Hospital Karachi from July 2009 to August 2012.

Patients and Methods: The gastric mucosal biopsies of 280 patients received at Dr. Tahir Laboratory from Gastroenterology unit of Hamdard University Hospital Karachi.

Results: A slight higher frequency of gastric disease seen in females with age range of 17 years to 78 years was observed. The clinical presentations mostly seen were abdominal pain, dyspepsia, vomiting, diarrhea, decreased appetite and weight loss. The histopathology revealed chronic active gastritis (H Pylori positive and negative) followed by malignant gastric ulcer. A number of biopsies were unremarkable histologically.

Conclusion: The more prevalent lesions in this series were chronic active gastritis. H. pylori associated gastritis was seen in majority of the patients. Thus gastric biopsy is an essential tool for diagnosis and confirmation of clinically suspected cases.