Prevalence of Ischemic Heart Disease and Dyslipidemias in Patients of Subclinical Hypothyroidism

Abstract

Objective: To determine the prevalence of ischemic heart disease and dyslipidemias in patients of subclinical hypothyroidism.

Study Design: Cross sectional observational study

Place and Duration of Study: This study was conducted at the Department of Medicine of Al-Nafees Medical College and Hospital, Islamabad from March, 2019 to August, 2019.

Materials and Methods: After hospital ethical committee approval the study was conducted. Demographic data such as age, gender, family history of thyroid disease and dyslipidemias were taken after fully informed consent. Patients with evidence of subclinical hypothyroidism were selected by thyroid profile after fulfilling of inclusion criteria and sub categorized on the basis of gender. Fasting lipid profile, ECG, ETT and Echocardiography were performed. Collected information was analyzed by using SPSS 23 version.

Results: The mean age of patients in our study was 51.21±5.94 year. 36(54.5%) were male and 30(45.5%) were female. In our study the cases of ischemic heart disease were 29(43.9%) and dyslipidemias were 27(40.9%). The mean value with standard deviation of serum cholesterol was 203.90±4.91 mg/dL, HDL was 23.97±4.43 mg/dL, LDL was 141.21±4.43 mg/dL and triglyceride was 139.97±4.11 mg/dL in patients of ischemic heart disease while in non-ischemic heart disease serum cholesterol was 156.81±12.47 mg/dL, HDL was 39.14±5.92 mg/dL, LDL was 107.00±12.11 mg/dL and triglyceride was 124.30±2.93 mg/dL. The p value for all was significant (p = 0.000).

Conclusion: In our study we concluded that there was high prevalence of ischemic heart disease and dyslipidemia in subclinical hypothyroidism patients