Uric Acid, Creatinine and Proteinuria: Do They Have any Relationship with Leptin During Pre-Eclampsia?

Abstract

Objective: To determine the relationship between serum leptin, uric acid, creatinine and proteinuria  during  pre-eclampsia.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: This study was carried out in the department of physiology, Basic Medical Sciences Institute, JPMC, in collaboration with the department of Gynaecology and Obstetric, JPMC from Jan 2007 to Dec 2007.

Materials and Methods: For this purpose 45 primigravidas with normal pregnancy and 45 primigravidas with pre-eclamptic pregnancy were selected who were in their third trimester. All the subjects were of the same maternal age, gestational age, height and weight. Serum leptin levels were determined by immunoenzymometric assay and total lipid profile was determined by enzymatic colorimetric method. Serum uric acid and serum creatinine were determined by uricase  method and jaffe’s method by photometric system. To perform the dipstick urine analysis, multistix URS-10 test strips were used.

Results: The study included 90 patients, divided into two groups. Serum uric acid was found to be significant in pre-eclamptic group (p<0.001) but there was no difference between serum creatinine of the two groups. No significant correlation was found between serum leptin, uric acid and creatinine. It was found that the level of leptin rises with the level of proteinuria.

Conclusion: From this study, it was concluded that serum leptin levels during pre-eclampsia were  not strongly associated with serum uric acid and creatinine but relation with proteinuria was found to be significant.