To Study the Effects of Simvastatin on Lipid Profile in Obese Patients with Changing Lifestyle

Abstract

Simvastatin is a competitive inhibitor of HMG-CoA (3-hydroxy 3-Methyl glutaryl Coenzyme A) reductase.

Objective: Present study proposed that the lipid lowering effect of simvastatin may be enhanced, if it was taken with fat free diet and morning walk.

Study Design: Cross Sectional Study.

Place and Duration of Study:  This study was conducted at Fatima Jinnah Medical College, Lahore for a period of six months from December 2009 to May 2010.

Patients and Methods: 20 male and 20 female obese patients were selected. The obese patients were re-examined three times i.e. before giving the simvastatin, then after 6 and 12 weeks. The patients were advised to take fat free diet and a morning walk. Serum Cholesterol, serum Triglycerides and serum Lipoprotiens (HDL, LDL) were determined.

Results: This study shows that with use of simvastatin, serum cholesterol, serum triglycerides, and serum LDL-Cholesterol was reduced significantly and serum HDL-Cholesterol increased significantly in both sexes. It was also observed that the fat free diet and some exercise causes weight reduction.

Conclusion: It is therefore concluded that simvastatin shows significant lipid lowering effects augment process of body weight reduction, if patients used calorie restricted diet with some morning walk.