Nurse-Led Preventive Interventions Regarding Hepatocellular Carcinoma Knowledge, Complications and Quality of Life among Chronic Liver Disease Patients

Abstract

Objective: To evaluate the effectiveness of a nurse-led preventive intervention on refining quality of life, disease- related knowledge, and complication lessening among patients with prolonged liver illness associated with hepatitis B, C, and Non-alcoholic fatty liver disease.

Study Design: Quasi-experimental pre–post study
Place and Duration of Study: This study was conducted at the Allama Iqbal Teaching Hospital, Dera Ghazi Khan from 1st July 2025 to 30th September 2025.

Methods: The link between the nurse led preventive education and health improvement was assessed among patients. A total of 24 chronic liver disease patients aged 28–55 years were registered. The data were collected using the Prolonged Liver Illness Questionnaire, the SF-36 Quality of Life Scale, and the HCC Knowledge Assessment Scale.

Results: Males are more with chronic liver disease than females which indicates that they are more exposed to the disease, mostly married. 83.3% improvement was seen among patients' symptoms due to following the preventive intervention. Mean difference has been reduced from 14.72 to 3.60. The systemic domain showed the highest mean difference (3.35). Fifteen (62.5%) have a good knowledge level, 8(33.3%) participants have a fair knowledge level, and only 1(4.2%) has a poor knowledge level. A Pearson correlation analysis was performed to check the association between the SF-36 Items. Mean and CLDQ 6 items Mean in which All SF-36 subscales correlated significantly with all scores of CLDQ subscales (p< 0.05).

Conclusion: Nurse-led preventive education has a significant influence on patients' chronic health conditions. Organized patient education is a key policy within hepatology facilities to improve long-term predictive markers and avoid the onset of hepatocellular carcinoma.