Causes of Acute Kidney Injury (AKI) in Pregnancy at Tertiary Care Center

Abstract

ABSTRACT

Objective: To find the frequency of common contributing factors of AKI during pregnancy.

Study Design: Descriptive, cross-sectional study.

Place and Duration of Study: This study was conducted at the Department of Nephrology and Obstetrics & Gynaecology, Fatima Memorial Hospital Lahore from 20^th December 2020 to 19^th June 2021.

Materials and Methods: One hundred and twenty female pregnant patients were any trimesters having acute kidney injury with ages between 18-45 years were included. Patients with renal transplantation and diagnosed CKD cases were excluded. Serum creatinine was measured at baseline along with complete blood count (CBC), peripheral blood smear, urine analysis, serum LDH, Coomb’s test, ultrasound abdomen and pelvis, ABGs to determine the common contributing factors of AKI.

Results: The frequency of common contributing factors of acute kidney injury were found to be sepsis in 68 (56.7%), pre-eclampsia/eclampsia in 55 (45.83%), pre-renal/ischemic ATN in 45 (37.50%), acute glomerulone-phritis in 11 (9.2%) and TTP/HUS in 08 (6.67%) patients.

Conclusion: Sepsis is the most common contributing factor of acute kidney injury in pregnancy followed by pre-eclampsia/eclampsia and pre-renal/ischemic ATN.