Oral Cancer: Correlation of Histopathological Grading and Location with Lipid Profile

Abstract

Objective: To compare the level of HDL, LDL, Triglycerides and Cholesterol in OSCC patients with that of healthy individuals and to find out the relationship between the level of HDL, LDL, Triglyceride and Cholesterol with location and histopathological grading of the tumor.

Study Design: Prospective Case-Control study

Place and Duration of Study: This study was conducted at the OPD of Jinnah Postgraduate Medical Center and Sindh Institute of Oral Health Sciences, from July, 2018 to December, 2019 for a period of one and a half year.

Materials and Methods: Sample size of 24 controls and 24 cases was calculated through open epi keeping in consideration Odds ratio of 7.1% from previous studies.

Results: LDL, HDL and Triglyceride levels increased while HDL decreased in Oral cancer patients in comparison to controls. We also compared the lipid profile levels with histopathological differentiation and location of the lesion finding out that the well differentiated tumor has lipid values within normal range except for LDL levels which becomes opposite in poorly differentiated squamous cell carcinoma.

Conclusion: Our findings are concurrent with previous studies that lipid profile varies with malignant transformation in oral cancer. Longitudinal studies are required to provide a definite conclusion on the matter.