Assessment Alpha-1-Antitrypsin and Correlation with Liver Enzymes in NonAlcoholic Fatty Liver Patients in Thi-Qar Province, Iraq

Abstract

Objective: The research aims to evaluate the relationship between alpha-1-antitrypsin and liver enzymes alanine 
aminotransferase and aspartate aminotransferase in patients with fatty liver disease. 
Study Design: Comparative study. 
Place and Duration of Study: This study was conducted at the University of Thi-Qar, Al-Nasiriyah Teaching 
Hospital, Iraq from 1st December 2023 to 1st May 2024 
Methods: Serum Alpha-1-antitripsin, alanine aminotransferase and aspartate aminotransferase levels were measured in 96 volunteers, 23 healthy control group members and 73 patients. An internist physician made the diagnosis for the patients. Patients with non-alcoholic fatty liver disease are the instances that were included, fatty liver to diabetes mellitus and hypertension. Individuals with fatty liver disease caused by alcoholism, or fatty liver along with other illnesses like cardiac and kidneys were excluded. 
Results: Significant decrease in the concentration of alpha-1-antitripsin in patient’s groups in comparison to the  control group (p≤0.05). Notable rise in the concentration of alanine aminotransferase in patient’s group comparison 
to controls groups (p≤0.05).notable rise in the concentration of aspartate aminotransferase in patient’s group comparison to controls groups (p≤0.05). 
Conclusion: The negative correlation between alpha-1-antitripsin and aspartate aminotransferase in the fatty liver 
group and the association factor (r= -0.13). A negative relationship between Alpha-1-antitripsin and alanine 
aminotransferase in the fatty liver group and the association factor (r= -0.26).