Frequency of Deranged Coagulation Profile in Pregnant Women Having Pregnancy Induced Hypertension

Abstract

Objective: To determine the frequency of deranged coagulation profiles in women having pregnancy-induced hypertension (PIH).

Study Design: Cross-sectional study.

Place and Duration of Study: This study was conducted at the Department of Gynecology and Obstetrics at Nishtar Hospital Multan from January 2023 to August 2023.

Methods: Overall, 370 patients were enrolled, 175 (47.3%) normotensive pregnant women, considered as Group A whereas 195 (52.7%) patients were gestational hypertension. The following variables were calculated and assessed, age, gravidity, gestational age, diagnosis of PIH, platelet count, clotting time, bleeding time, PT, and aPTT.

Results: The mean platelet count of Group A and Group B was 2.59±0.63 and 2.55±0.55, respectively. The distribution of platelet count in both groups was almost equal. The mean platelet volume of groups was 8.89±0.88 and 8.68±0.75, respectively. The mean prothrombin time of Group B was greater than Group A, 19.33±3.59 minutes, and 14.45±2.42 minutes, respectively. Most of the patients of Group B had prolonged prothrombin time 74.9% versus 20.0% for Group A. The mean aPTT of Group B was greater than Group A, 39.61±7.78 and 31.40±6.52, respectively. Most of the patients 63.6% in Group B had prolonged aPTT.

Conclusion: Platelet counts exhibited an inverse relationship with pregnancy-induced hypertension (PIH), while prothrombin time (PT) and activated partial thromboplastin time (APTT) showed a direct relationship with increasing severity of PIH as it increases with increase in blood pressure.