Relevance of High Sensitivity C-Reactive Protein (hs-CRP) Level in Patients with Acute Coronary Syndrome (ACS) and Short Term Outcome

Abstract

Objective: To evaluate the relevance of High Sensitivity C-Reactive Protein (hs CRP) level in patients with acute coronary syndrome (ACS) and short term outcome.

Study Design: Cross-sectional study.

Place and Duration of Study: This study was conducted at the Department of Cardiology, Liaquat University Hospital Hyderabad for six months from 15^th March 2018 to 14^th September 2018.

Materials and Methods: The ACS (ST elevated Ml, non-ST elevated MI, and Unstable Angina) patients were confirmed based on clinical history, ECG, Cardiac Enzymes, cardiac markers (Troponins), and further evaluated for hs-C-reactive protein levels. The data were analyzed in SPSS version 16.

Results: A total of 60 patients with acute coronary syndrome were recruited i.e. 40(00.7) STEML, 14(23.3%) NSTEMI, and 6(10%) unstable angina. The mean CRP level of intermediate-risk was 2.51±0.51, p<0.001, high-risk 10.95+7.7, pp<0.001, and low risk 0.862±0.51. There are significant values (<0.05), and 2(9.5%) died in the low-risk group. Six (85.7%) alive and 14 (43.75%) die in a high-risk group, 4 (19%) in the low-risk group, 1(14.3%) in the intermediate-risk group, and 8(25%$) high-risk group were hospitalized within three months. The mean ± SD of CRP with STEMI, NSTEMI, and UA was 6.82±8.0, 5.11±5.9, and 4. 63±8.2 (p=0. 05). 

Conclusion: Serum hs-CRP levels show a significant correlation with the acute coronary syndrome. Measurement of C-reactive protein may have clinical significance in the management of patients hospitalized for the confirmed acute coronary syndrome.