The Effect of Pre-Infarct Angina on Post-Myocardial Infarction Left Ventricular Ejection Fraction in Patients of Acute ST Elevation Myocardial Infarction Treated With Streptokinase

Abstract

Objective: To determine the effect of pre-infarct angina on post-MI left ventricular function in patients with acute 
STEMI. 
Study Design: Comparative study 
Place and Duration of Study: This study was conducted at the Department of Cardiology, Bahawal Victoria 
Hospital, Bahawalpur, from May 2018 to October 2018.  
Materials and Methods: Two hundred and thirty patients admitted to the Cardiology Department with the 
diagnosis of acute STMI who subsequently received thrombolytic therapy were enrolled in the study. The data were 
recorded on a performa which included demographic characteristics, history of risk factors for coronary artery 
disease, time from symptom onset to presentation; and the presence or absence of pre-infarction angina. All the 
enrolled patients underwent 2-dimensional echocardiography to assess left ventricular ejection fraction before 
discharge. The data was entered and analyzed with SPSS version 20. The patients were divided into two groups 
depending upon the presence or absence of pre-infarct angina. The categorical variables were compared between the 
two groups with chi-square test. The left ventricular ejection fraction was compared between the two groups with 
two-tailed t-test. A p value of <0.05 was considered to be significant. 
Results: Pre-infarct angina was present in 58.7 % of the patients. There were no significant differences with regards 
to baseline characteristics in patients who experienced pre-infarct angina as compared to those who didn’t have pre
infarct angina. Post-MI ejection fraction was significantly higher in patients who experienced pre-infarct angina. 
Conclusion: The patients with pre-infarct angina have better post-MI left ventricular ejection fraction.