A Serum Level and Polymorphism of Interleukin -17 Gene (RS 8193036, RS 2275913) in Scabies Patients

Abstract

Objective: To assess how genotyping affects an individual's likelihood of developing scabies.

Study Design: Cross-sectional study.

Place and Duration of Study: This study was conducted at the Baquba Teaching Hospital- Consultation Clinic- Dermatology Unit/ Diyala Governorate from 4^th of December, 2022 to 10^th June, 2023.

Methods: Seventy-five male and female volunteer patients who clinically diagnosed with scabies and 75 non-infected individuals as a control were enrolled.

Results: There was an increase in IL-17 concentration of the patients' serum compared with control and there was genotype variation in both studied single nucleotide polymorphisms.

Conclusion: The serum level of IL-17 was increased in scabies group, the GA genotype and G allele of IL-17 SNPs rs 8193036 and the TT,CT genotypes and T allele of rs 2275913 were increased too with high OR value, the genotypes and alleles   might be a risk factors from scabies infestation.