Streptokinase Study on ST Segment Resolution in Patients age Less Than 40 Years with Myocardial Infarction

Abstract

Background: Thrombolytic therapy for Acute Myocardial Infarction has been one of the most potent treatment ever 
developed for condition that kill more patients worldwide than any other. 
Objective: To evaluate the benefit and efficacy or observational studies of streptokinase therapy on ST-segment 
elevation resolution in different types of myocardial infarction that focus especially on the younger age group less 
than forty years. 
Study design: To observe the streptokinase therapy, in ST-segment elevation resolution, in age less than 40 years 
and in different types of myocardial infarction.  
Place and Duration of Study: The study was conducted at national institute of cardiovascular diseases (NICVD) of 
Pakistan, Karachi. 
Materials and Methods: All patients fulfilling the inclusion criteria for thrombolytic therapy were included. 
Baseline ECG recorded before streptokinase infusion and repeated at completion of infusion i.e. 90 minutes, day 1 
and day 2. 
Results: Streptokinase therapy on blood pressure, CKMB, and ST-segment resolution at 90 minutes, day 1, and 
Day2 in less than 40-year of age patient. The mean systolic blood pressure was 124+ 3.32 and 112+3.00  pre and 
post SK therapy reflecting a percentage decrease of 6.67 and highly significant (P<0.001). The Diastolic blood 
pressure was decrease to 6.25% with a mean value of 76.80+ 2.70 and 72+1.91 before and after the Streptokinase 
therapy’s, segment resolution at 90 minutes was decreased to 52.01 percent from the baseline and continued to 
decrease at Day-1 and Day-2 with a percentage reduction of 70.65 and 83.69 % respectively. The P values were 
highly significant (P<0.001). 
Conclusion: Thrombolysis improves survival when given within 12 hours of the onset of symptoms. The magnitude 
of benefit is greatest when reperfusion is established early. Age itself should not be considered a contraindication for 
fibronolysis