Histopathological Hepatoprotective Effects by Echinops Echinatus A Plant from Cholistan Desert

Abstract

Objective of study: Aerial parts of Echinops Echinotus (EE) were subjected to in vivo histological hepatoprotective 
study in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan desert, Pakistan. 
Design of Study: Experimental study.  
Place of study:  The study was conducted at PCR lab Multan. 
Materials and Methods: The animals were randomly divided into three groups, containing 10 rabbits in each 
group. Histological hepatoprotective effects of pre-treatment with aerial parts (ethanolic extract) of EE (500 and 750 
mg/kg/day PO for 7 days) against CCl4 (0.75 ml/kg, S/C) intoxicated rabbits were evaluated by liver histological 
observations. Silymarin (100 mg/kg/day PO for 7 days) was used as a standard hepatoprotective drug. 
Results: CCl4 intoxicated group had significant histological changes (marked fatty changes etc.) as compared to 
normal control group. However, EE extract produced significant histological hepatoprotective changes. 
Conclusion: Therefore, the outcome of present study supports the traditional behaviour on hepatoprotective effects 
of Echinops  Echinatus (aerial parts).