Evaluation of Histopathological and Biochemical Hepatoprotective Potentials of Fagonia Bruguieri A Plant from Cholistan Desert

Abstract

Objective: Aerial parts of Fagonia Bruguieri (FB) (family, zygophyllaceae)  were subjected to in vivo 
hepatoprotective study in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan 
desert, Pakistan. 
Design of Study: Experimental study.  
Place of study:  This study was conducted at PCR lab Multan. 
Materials & Methods: The animals were randomly divided into three groups, containing 10 rabbits in each group. 
Hepatoprotective effects of pre-treatment with aerial parts (ethanolic extract) of FB (500 and 750 mg/kg/day PO for 
7 days) against CCl4 (0.75 ml/kg, S/C) intoxicated rabbits were evaluated by serum biochemical parameters and 
liver histological observations. Silymarin (100 mg/kg/day PO for 7 days) was used as a standard hepatoprotective 
drug, 
Results: CCl4 intoxicated group had raised levels of SGOT, SGPT and ALP sTignificantly but TB level was not 
raised as compared to normal control group. FB extract (both doses of 500 and 750 mg/kg) showed hepatoprotection 
as obvious by significant reinstatement of levels of SGOT, SGPT and ALP while TB level was not changed 
significantly, when compared with CCl4 intoxicated group. Both doses of FB extract were well comparable with 
silymarin. Histopathological examination of the liver tissue further corroborated these results.   
Conclusion: Therefore, the conclusion of the present study supports the traditional believes on hepatoproptective 
effects of Fagonia Bruguieri (aerial parts).