Vitamin E Ameliorates Renal Damage in Streptozotocin induced Diabetes in Albino Rats

Abstract

Aims and Objectives:  This study was designed to find out the role of Vitamin E on serum glucose and Creatinine 
concentrations of male albino rats made diabetic by streptozotocin.  
Study Design: Prospective study.  
Place and Duration of Study: This study was conducted at the Department of Physiology; Basic Medical Sciences 
Institute (BMSI), Jinnah Post Graduate Medical Center (JPMC), Karachi from Feb. 2010 to March 2010. 
Materials and methods: In a 4 weeks study, 45 male albino rats were divided into 3 groups containing 15 animals 
each. Group A was treated as control, Group B and Group C received 45 mg/kg STZ once at the start of the 
experiment whereas Group C additionally received 600 mg/kg Vitamin E Intramuscularly 3 times weekly. Serum 
glucose and Creatinine concentrations were measured at the beginning of the experiment and once weekly. 
Results: Serum glucose and Creatinine levels were significantly elevated in Group B as compared to control. In 
Group C, blood glucose was elevated but the levels of serum Creatinine were significantly reduced, when compared 
to group B.  
Conclusions: Our findings conclude that Vitamin E supplementation may have protective effects against 
deterioration of renal function brought about by free radical toxicity in diabetes mellitus.