Evaluation of Centella Asiatica for its Neuropharmacology

Abstract

Objective: To determine the effect of Centella Asiatica on Neuro pharmacological activities as memory, behavior 
(anxiety, depression). 
Study Design: Experimental Study. 
Place of study: This study was conducted in the department of Pharmacology, Faculty of Pharmacy, University of 
Karachi, Karachi from 15th March 2011 to 30th April, 2011. 
Materials and Methods: Albino mice and albino rats were used. Animals were divided into control and treated 
groups (10 animals each). Neuro pharmacological parameters were assessed using standard techniques as Stationary 
rod activity, Swimming induced depression (FST), Open field, Light and dark box test and water maze model. 
Control group was maintained on distilled water and treated group was fed with 8.3 mg/kg Centella asiatica for 10 
days. Observations were taken on 1st, 5th and 10th days.  
Results: The results showed decline in the elapsed time taken by animal to reach the platform in Stationary rod and 
water maze model, significantly enhanced struggling time in FST, decreased number of peripheral square crosses 
but relatively increased central square crosses on 10th day in open field test and increased time spent in light box in 
Light and dark box model. 
Conclusion: It can be concluded that Centella asiatica enhances memory and show antidepressant activity on acute 
administration while chronic use results in anxiolytic behavior.