CNS Stimulant Activity of Qurs Saffron (A Herbal Medicine) in Experimental Animal Models

Abstract

Objective: To confirm the safety and efficacy of the product for human health due to its wide use and to explore its 
effects on CNS.  
Study Design: Experimental and observational 
Place and Duration of Study: This study was conducted at Frontier medical college Abbottabad Pakistan in  
March 2011. 
Materials and Methods: Thirty rabbits divided into five groups were administered Qurs saffron at the dose of 50, 
100 and 200 mg/kg, Caffeine 100mg/kg orally and the last group was taken as control group, received normosaline. 
The animals were observed for behavioral changes at 30 min intervals. 
Results: At 50mg/kg of the drug were found to have mild stimulant activity, while 100mg/kg were found to have a 
moderate CNS stimulant properties same like caffeine at a dose of 50mg/kg. While at a dose of 200mg/kg Qurs 
saffron were found to have a strong stimulant properties. 
Conclusion:  From the current study it can be concluded that the product have dose dependent CNS stimulant 
effects.