Incidence of Diastolic Dysfunction in Poorly Controlled Type 2 Diabetes Mellitus without Hypertension and Coronary Artery Disease

Abstract

Objective: The purpose of this study was to study the incidence of left ventricular diastolic dysfunction in type 2 
diabetes mellitus patients without hypertension and coronary artery disease and its relation to duration of diabetes 
mellitus.
Study Design: Descriptive case series study
Place and Duration of Study: This study was conducted at the Department of Medicine of Al- Nafees Medical 
College & Hospital, Islamabad from April, 2019 to September, 2019.
Materials and Methods: Patients with diabetes mellitus between age of 40 -70 years with poor glycemic control 
having HbA1c >9% and without history of hypertension, coronary artery disease, heart failure, or valvular heart 
disease were recruited. The study was conducted after the approval from hospital ethical committee. All the patients 
were educated and an informed written consent was taken. Exercise tolerance test and Resting ECG were done on 
every subject to exclude ischemia and echocardiography was performed to assess left ventricular.
Results: A total of 60 poorly controlled diabetic type 2 patients meeting inclusion and exclusion criteria of this 
study were registered. Of these 60 study cases, 26(43.33%) were male and 34(56.66%) were female. Diastolic 
Dysfunction was found to be present in 37(61.66%) while it was found to be absent in 23(38.33%) of poorly 
controlled diabetic (type 2) patients without coronary artery disease as well as hypertension.
Conclusion: Diastolic Dysfunction is very common, over 60%, in poorly controlled type 2 diabetic patients and this 
finding correlates with HbA1c levels and duration of diabetes mellitus and does not correlate with age and gender