Lithium Induced Male Reproductive Organ Injury in Albino Rats

Abstract

Objective: Metal ingestion causes degenerative injury to seminiferous tubules and antipsychotics drugs like Lithium   brings deleterious changes to seminiferous tubules in this study the diameter of seminiferous tubules was measured and documented.

Study Design: Experimental study

Place and Duration of Study: This study was conducted at the Anatomy department and Animal house of Basic Medical Sciences Institute from May, 2013 to June, 2013 for a period of 02 months.

Materials and Methods: Three months of age weighing 270 -290 grams were chosen for this study and distributed into two equal groups A and B. Group A served as control, received only laboratory   diet group B received Table Lithium Carbonate 20 mg/kg body weight for four weeks. At end of the study period   the dissection of lower abdomen was carried out and testis were removed and the diameter of seminiferous tubules in both groups were measured and documented.

Results: The total number of albino rats selected for this study was twenty. The results showed a highly significantly increased diameter of seminiferous tubules P value <.001 in Group A animals as compared to group B animals and a highly significantly decreased P value < .001 diameter of seminiferous tubules in Group B Animals as compared to Group A rodents.

Conclusion: Lithium carbonate causes highly significant decreased thickness of seminiferous tubules.