Study on Presentations and Treatment Outcome of Plasmodium Falciparum Malaria

Abstract

Objective: To determine the presentation and treatment response to anti malarial drugs of Plasmodium Falciparum malaria.

Study Design: Descriptive / prospective study.

Place and Duration of Study: This study was conducted at the Department of Medicine, PMCH Nawabshah from January 2016 to April 2017.

Materials and Methods: 100 patients were selected for this study, statical analysis was done using SPSS 15 version.  Inclusion Criteria is ICT Malaria test positive for Plasmodium Falciparum. Thick and Thin flim positive MP Plasmodium Falciparum. Exclusion Criteria is ICT Malaria test, and thick thin film negative for Plasmodium Falciparum, tuberculosis and typhoid fever.

Results: 100 patients were selected for this study, 53 were males, 47 were females. Age ranged 13-70 years. All patients presented with fever, temperature ranged 100⁰F-105⁰F.Anemia was present in 40 patients, 20 patients were jaundiced clinically. Altered consciousness was present in 30 patients. 18 patients had raised blood urea, bilirubin was raised in 20 patients, hemoglobin ranged 4-14 gm/dl, TLC ranged 6320-24209/mm³, random blood sugar ranged 85-199 mg/dl, platelets ranged 40500-488245,PT was raised in 20 patients, LFT deranged in     patients. All patients treated by inj. Artesunate2.5 mg/kg i/v BD for 1 day then daily . Out of 100 patients 13 died due to severity of disease.

Conclusion: Plasmodium Falciparum Malaria with complications is a major illness in our country especially patients from rural areas. Patients reach very late in hospital, Cerebral Malaria can be treated with artesunate atemether and quinine. Prevention and awareness is is necessary, mortality can be reduced.