Frequency of Vitamin B12 in Patients with Diabetic Peripheral Neuropathy

Abstract

Objective: To determine the frequency of vitamin B12 deficiency in patients with diabetic peripheral neuropathy

Study Design: Descriptive / cross sectional study

Place and Duration of Study: This study was conducted at the Department of Medicine, HMC Peshawar from
Jan to Dec 2016.

Materials and Methods: A total of 135 patients were studied by using (22%) 8 proportion of vitamin B12 deficiency in patients with diabetes, 95% confidence level and 7% margin of error using WHO software for sample size. The SPSS latest version was used to analyze the data. For continuous data while for categorical one frequencies and %ages were calculated and the dated was prepared in tabulated form

Results: In this study 135 diabetics fulfilling the inclusion criteria were enrolled. We found mean age 56 years with SD ± 1.34. Fifty six percent cases were male and rest of 44% patients female. Mean duration of diabetes was 20 years with standard deviation ± 1.26. Twenty six percent patients had S Vit B12 level < 200 pg/ml and 74% patients had S Vitamin B12 level> 200pg/ml. On this basis S Vit B12 Deficiency was found in 26% patients while 74% patients didn’t had S Vit B12 Deficiency.

Conclusion: Patients with diabetes have both clinical and biochemical prevalence of vitamin B12 deficiency. Homocysteine and methylmalonic acid levels can estimate B12 deficiency and diabetic and non-diabetic.