Frequency of Glucose 6 Phosphate Dehydrogenase Deficiency in Patients with Plasmodium Vivax Malaria Presenting to a Tertiary Care Hospital

Abstract

Objective: To determine the frequency of glucose 6 phosphate dehydrogenase (G6PD) deficiency in patients with plasmodium vivax malaria presenting to the department of Medicine , Hayatabad Medical Complex, Peshawar.

Study Design: Descriptive / cross sectional study

Place and Duration of Study: This study was conducted at the Department of Medicine, Hayatabad Medical Complex, Peshawar from January 2016 to December 2016.

Materials and Methods: Patients with plasmodium vivax malaria were included and patients having evidence of acute hemolysis were excluded from the study. The G6PD level was measured in the Department of Pathology, HMC. The data collected was analyzed in SPSS latest version. Mean ± SD was calculated for continuous variable. Frequencies and percentages were calculated for categorical variables final results were presented in tables.

Results: A total of 870 patients were included. We found that 53(6.09%) subjects were deficient in G6PD. These cases were divided into non hospital and hospital groups. In Non-hospital group G6PD deficiency was 4.1% while13.3 % in the other group.  Thirty three patients (63.3%) had anemia in hospital patients and 8 patients had severe anemia. None of the Non-hospital had severe anemia, while mild anemia was observed in 16(30.2%) patients in Non-hospital groups.

Conclusion: G6PD deficiency is predominantly found in male population. Moreover anemia is more common in G6PD deficient people than normal population.