Comparison of Effects of 10% Zinger, 10% Fenugreek and 10% Garlic with Atorvastatin in Hypercholesterolemia Induced Rats

Abstract

Objective: Comparison of effects on lipid profile and hepatic enzymes by using 10% ginger, 10% fenugreek and 10% garlic against atorvastatin treated animals in hypercholesterolemia induced albino rats.

Study Design: Descriptive comparative experimental study.

Pace and Duration of study: This study was conducted at the Department of Biochemistry, Al-Tibri Medical College, Karachi from January 2016 to December 2016.

Materials and Methods: In the present study thirty six rats having weight of about 150-200 grams were included. The rats were further grouped into six A, B, C, D, E and F with six rats in each group. Group A (control) rats were kept on normal rat diet. Group B rats were kept on hypercholesterolemic diet containing 20% fat and 1% cholesterol. Group C rats were kept on supplemented diet having 10% ginger powder with hypercholesterolemic diet. Group D rats were kept on supplemented diet having 10% Fenugreek seed powder with hypercholesterolemic diet. Group E rats were kept on supplemented diet having 10% garlic with hypercholesterolemic diet. Group F rats were kept on 10mg/kg of atorvastatin in hypercholesterolemic diet.

Results: Significant decrease in triacylglycerol in group C (10% ginger) was noted as compared to group E (10% garlic) and F (Atorvastatin 10mg/kg of diet). Also the values of HDL were significantly higher in group C in comparison to the group D, E and F. However significant decrease in the level of total cholesterol is found in F (Atorovastin) group as compared to C and D group. Also the values of LDL were significantly lowered in group F in comparison to the group C, D and E. Alanine aminotransferase and Aspartate aminotransferase lowered significantly in group C in comparison to the group E. Alkaline phophatase was also significantly lowered in group C in comparison to D and E group but had shown no significant difference as compared to group F.

Conclusion: Zinger 10% supplementation improved the HDL and triacylglycerol levels as compared to other herbs and atorvastatin treated group. However atorvastatin treated group showed more decreased LDL levels. No significant difference was found in hepatic protection when ginger and others were compared to atorvastatin group.