Comparing the Effectiveness of Lisinopril and Losartan Potassium in Treatment of Microalbuminurea in Newly Diagnosed Type II Diabetes Mellitus

Abstract

Objective: is to compare effectiveness of Lisinopril (ACE inhibitor) and Losartan Potassium (ARB) in treatment of microalbuminurea in newly diagnosed Type II DM patients in terms of reduction in microalbuminurea.

Study Design: Randomized control trial study.

Place and Duration of Study: This study was conducted at the Department of General Medicine, Allied Hospital, Faisalabad from March 2016 to August 2016.

Materials and Methods: A total number of 320 (100%) patients was enrolled in the trial.SPSS (v 23) was used to analyze the patient’s data. Mean and SD were calculated and presented for numerical data and frequency percentages were calculated and presented for qualitative data. Chi square test was applied to see effect modification. P value ≤ 0.05 was considered as significant.

Results: A total number of 100% (n=320) microalbuminurea in Type II DM patients were included in this study, both genders. In our study in group (P), 85% (n=136) patients showed reduction in microalbuminurea and in group (L), 81.9% (n=131) patients were observed reduction in microalbuminurea. To compare the efficacy of Losartan Potassium and Lisinopril, independent sample t-test was applied. It was observed that there was no significant difference between the efficacies of Losartan Potassium and Lisinopril, i.e. these two drugs were equally effective with p-value 0.454.

Conclusion: From results of our study it is concluded that Lisinopril and Losartan potassium, both are significantly effective in reduction of microalbuminuria and can be advised as first line therapy in diabetes mellitus type II patients.