Anti-Inflammatory Effects of 1% Aspirin Gel and Mouthwash on Clinical Parameters and on Salivary PGE2 Conc. in Periodontal Diseases: A Clinical Study

Abstract

Objective: The objective of this study was to develop 1% aspirin gel and mouthwash to determine its local effects in patients with periodontal diseases in order to prevent the systemic adverse effects associated with its oral use.

Study Design: Randomized control trial study.

Place and duration of study: This study was conducted at the Department of Pharmacology, University of Karachi and also Crown Dental Clinic, Karachi from July 2015 to December 2015.

Materials and Methods: 40 patients were included and divided into four groups. 1) Control group received no treatment, 2) Standard treatment group received only scaling and root planning.3) Gel treated group,1% gel was applied into the periodontal pocket of patients after scaling and root planning. 4) Mouthwash treated group, 1% mouthwash was given to the patients after scaling and root planning. The clinical parameters and the level of PGE₂ were measured at day 0 and after 30 days of treatment in the all groups. Analysis was done by one way ANOVA followed by Bonferroni test where p≤ 0.05 was considered significant.

Results: Both the gel and mouthwash were very effective in reducing the clinical parameters and PGE₂ level as compared to standard and control group. The mouthwash in comparison to gel was more effective in reducing the level of PGE₂.

Conclusion: We concluded from this study that local drug preparations produced significant effects in the treatment of periodontal diseases and can prove an alternate to the systemic treatment.