Drug Resistance Patterns of Acinetobacter Baumanii Infection in Intensive Care Unit of a Tertiary Care Hospital of Sindh

Abstract

Objectives: The present study evaluated the drug resistance patterns of Acinetobacter baumanii infection in Intensive care unit of a tertiary care hospital of Sindh.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at Indus Medical College Hospital, Tando Muhammad Khan, Sindh, Pakistan from June 2015 to November 2016.

Materials and Methods: Of 521 samples, the A. baumaniiwere detected in 95 samples. API 20 E kit (Biomeriuex,USA) was used for the bacterial identification. Antibiotic susceptibility was checked by the Kirby-Bauer disk diffusion method (Oxoid, UK) and E- test (AB BIODISK, Sweden). E-test was used for the intermediate drug sensitivity or resistance was noted. Data was analyzed on GraphPad Prism software.

Results: Of 521 samples inoculated the A.baumanii was isolated from the 95 samples, this yielded a frequency of 18.23%. Drug resistance was noted for the amikacin, minocycline, tazocin, imipenem, meropenem, ceftazidim, cefixime, ceftriaxone and cefepime. A.baumanii showed no resistance for the Colistin.

Conclusion: The present study shows drug resistant A. baumanniiin intensive care units of a tertiary care hospital. A. baumanniishows drug resistance against the aminoglycosides, tetracylcines and cephalosporins.