Factors Predicting In-Hospital Mortality in Patients with Liver Cirrhosis

Abstract

Objective: To identify the independent predictors of in hospital mortality in gastro esophageal variceal hemorrhage in cirrhotic patients.

Study Design: Cross sectional

Place and Duration of Study: This study was conducted at the Gastroenterology department of Bakhtawar Amin Hospital and Nishtar hospital Multan from March 2018 to March 2019.

Materials and Methods: 250 patients were included in study. Laboratory and clinical parameters were assessed for their association with in hospital mortality. Laboratory parameters included were serum creatinine, serum bilirubin and clinical parameters were child pugh score, ascites and re-bleed within 24 hours of endoscopy. SPSS version 23 was used for data analysis.

Results: Hemoglobin (g/dL), prothrombin time, S. bilirubin (mg/dL), S. creatinine (mg/dL) and S. albumin (g/dL) of the survivors was observed as 4.9%, 7.6%, 4.9%, 8.9% and 2.7%, respectively. While, hemoglobin (g/dL), prothrombin time, S. bilirubin (mg/dL), S. creatinine (mg/dL) and S. albumin (g/dL) of the non-survivors was observed as 12%, 12%, 12%, 8% and 4% respectively. P value ≤0.05was considered as significant.

Conclusion: Raised values of serum bilirubin, serum creatinine, re-bleeding within 24 hours of endoscopy and presence of PSE were the main independent predictors of in hospital mortality. Control of these parameters with advance management and specialized care is helpful to reduce in hospital mortality rate.