Hypothyroidism in Women Can Lead to Recurrent Miscarriages

Abstract

Objective: To determine the frequency of hypothyroidism inpatients presenting with the history of recurrent miscarriages at tertiary care hospital in Larkana

Study design: Descriptive / cross-sectional study

Duration and place of study: This study was conducted at Shaikh Zaid Women Hospital, Obstetrics and Gynecology Unit-II, SMBBMU, Larkana from March, 2016 to September, 2016.

Materials Methods: Total eightypatient having age between 18-35 years, parityat least para 1 and history of recurrent miscarriages were included in this study. After taking approval from an ethical reviewcommittee of the institute. Blood sample was taken & sent to a central laboratory for serum analysis of TSH and free T4 levels. Hypothyroid patients were treated with thyroxin. Data was collected on a predesigned proforma. The data was analysed using SPSS version 17.

Results: Mean age of enrolled participants was 26.8±4.3 years,the mean parity was 1.79±0.74 and 66 (82.5%), 37 (46.3%) had income <10000 a month, 22 (27.5%) had three miscarriages, the mean duration of pregnancy was 14.19±1.71 weeks, mean TSH level was 3.48±1.7 and mean free T4 level was 4.55±1.1. The frequency of hypothyroidism in patients presenting with recurrent hypothyroidism was 26 (32.5%) cases.

Conclusion: In conclusion, the prevalence of thyroid autoimmunity was higher in pregnant women with a history of recurrent abortion. The frequency of hypothyroidism in patients presenting with recurrent miscarriage was statistically significant in poor patients and frequency of hypothyroidism increases as a number of abortions increases.