Efficacy of Rosuvastatin 10mg with Atorvastatin 20mg in Lowering Low Density Lipoprotein Cholesterol in Hypercholesterolemia Patients

Abstract

Objective: To measure the effectiveness of Rosuvastatin 10mg with Atorvastatin 20mg in lowering low density lipoprotein cholesterol.

Study Design: Retrospective study

Place and Duration of Study: This study was conducted at the Jinnah Hospital, Lahore from March 2017 to December 2017.

Materials and Methods: 252 patients were enrolled having equal subjects in each group, using efficacy of Rosuvastatin 50 %(1) and efficacy of atorvastatin 39 %(1) with 95% confidence interval and 80% power of test.

Results: In Rosuvastatin group mean age was 65 years with SD ± 1.61 with male patients 51% and female patients were 49%. While in Atorvastatin Group mean age was 63 years with SD ± 1.93 with 54% patients were male and 46% patients were female. Moreover it was showed that Rosuvastatin appeared to be potent among 82% of the individuals and was not efficacious in 18% of the individuals while Atorvastatin was efficacious in 71% of the individuals and was not beneficial in 29% of the individuals.

Conclusion: In individuals having hypercholesterolemia, it was found that atorvastatin 20 mg is non-superior than Rosuvastatin 10 mg in lowering LDL-C, enabling LDL-C goal towards healthy target values.