A Comparative Analysis of Lithium Induced Cerebellar Cortical Toxicity in Albino Rats

Abstract

Objective: To compare the thickness of cerebello cortical gray matter of albino rats after chronic ingestion of Lithium carbonate.

Study Design: Prospective experimental study

Place and Duration of Study: This study was carried out in Animal House affiliated with atomy department BMSI, JPMC, Karachi from April 2012 to June 2012.

Materials and Methods: Thirty male albino rats of 100-200 grams were selected and divided into two major groups A and B. Each major group consisted of 15 animals and my study was conducted according to the time period of the study which was 2 weeks, 6 weeks and 12 weeks. The control group purpose was served by Group A which was given lab diet and B was the Lithium treated group. Lithium carbonate (ADAMJEE PHARMACEUTICALS) was given at a dose of 20mg/kg/day for 2, 6 and 12  weeks. Cerebellar Gray matter thickness was measured at 2^nd, 6^th and 12^th weeks in the normal healthy control group and Lithium treated group.

Results: Group B showed a progressive decrement of gray matter as the time period of study advance.

Conclusion: The present study concluded that Lithium carbonate causes a significant decrease of cerebello cortical gray matter.