Prevalence of Urinary Tract Infection in Patients with Urinary Stone Disease and Their Antibiotic Sensitivities

Abstract

Objective: To find out the frequency of common bacteria causing urinary tract infection in patients with urinary stone disease and to determine the antibiogram of common bacteria causing urinary tract infection  in patients with urinary stone disease.

Study Design: Cross-sectional study

Place and Duration of Study: This study was conducted at Urology Out-patient Department, Shaikh Zayed Hospital Lahore from 1^st February 2020 to 30^th July, 2020.

Materials and Methods: Sixty five patients with urinary stone diseases were enrolled. All urinary stone patients of both genders and 13-65 years were included. their clean-catch mid-stream urine samples were sent to microbiology laboratory for culture and sensitivity testing.

Results: The mean age was 45.09±15.49 years with 35 (53.8%) male and 30 (46.2%) female patients. The most common pathogens isolated were E. coli (61.5%), K. Pneumonia (9.2%), Enterococcus species (9.2%), methicillin-resistant Staphylococcus aureus (6.2%) and P. mirabilis (4.6%). Most of the isolates were found to be highly resistant to commonly prescribed antibiotics including cephalosporins, quinolones and penicillin-derivatives.

Conclusion: An overall high prevalence of E. coli causing UTI in patients with USD. For gram-positive isolates, low levels of resistance were detected against teicoplanin, linezolid and vancomycin while gram-negative isolates were most sensitive to colistin, meropenem and imipenem. Multi-drug resistant urinary tract bacteria are becoming widespread in patients with USD, probably due to frequent and unwarranted use of antibiotics. The surveillance of UTI and antimicrobial resistance patterns are essential to reduce the emergence of more resistant strains of these bacteria.