Frequency and Clinico Pathological Features of Diffuse Large B Cell Lymphoma - A Tertiary Care Center Experience

Abstract

Objective: To determine the frequency and study the clinicopaological features of DLBCL.

Study Design: Descriptive study

Place and Duration of Study: This study was conducted at the Department of Pathology, King Edward Medical University , Lahore from 2013 to 2017. 

Materials and Methods: One hundred and seventy two consecutive cases of  Non Hodgkins  lymphoma  referred for bone marrow biopsy were enrolled in the study. All the cases were diagnosed on histological biopsies. The patients  receiving chemotherapy or radiotherapy were excluded from the study.

Results: Out of 172 patients 05 (2.9%) had T cell NHL and  167  ( 97.1%) had B cell lymphoma. Out of these B cell NHL 46 (26.7%) cases were of diffuse large B cell lymphoma. Cytopenias were observed in 32.6 % of patients. In 13 % patients bone marrow was infiltrated. The pattern of infiltration was diffuse.

Conclusion: DLBCL is a frequently presenting aggressive NHL having  hcetrogenous clinical behavior.