Comparative Study of Chromium Toxicity with Hypertension and End Stage Renal Failure Cases

Abstract

Objective: To assess the association between hypertension and chronic renal failure with lethal effects of chromium on the beginning of the Chronic Kidney disease.

Study Design: A prospective cross sectional study.

Place and Duration of Study: Jinnah post graduate medical centre and Kidney centre Karachi during December 2012 to December 2013.

Materials and Methods: The present study was conducted on a total of 150 patients (age > 40 years) divided into three groups. Patients in Group I included 50 patients with hypertension whereas Group II included 50 patients with hypertension associated with chronic renal failure (CRF) and Group III consisted of 50 healthy controls.

Results: Results showed that levels of fasting blood sugar and HbA1c in both group I and group II were significantly higher as compared to controls. The levels of serum urea (132.0 ± 28.2) and creatinine (7.8 ± 1.38) in group II patients were significantly high as compared to group I and group III patients. The Creatinine clearance (55.1 ± 9.61) in group II patients were significantly less as compared to group I and group III patients. Serum chromium levels were significantly high in group II patients( 59.6 ± 6.73) as compared to  group I and controls.

Conclusion:  Serum chromium level has significant correlation with glycemic index in both group I and group II patients compared to controls, while correlation with renal failure was significant only in group II patients.