Association Between Periconceptional Folic Acid Deficiency and Occurrence of Skeletal Anomalies in Newborns

Abstract

Objective: This study was planned to detect the connection among environs component (folic acid inadequacy) and development of Skeletal anomalies during intrauterine life.

Study Design: Case control study.

Place and Duration of Study: This study was conducted at the CLAP Hospital Johar Town and Arif Hospital Kasur from 1^st January 2014 to 31^st Dec. 2014.

Materials and Methods: It was a suitable sampling, two existing groups  differing in outcome were identified and compared among, 100 sufferers of CLP and  allied skeletal anomalies in neonates age not more than 6 months, in various Hospitals of Lahore. Mothers were asked whether they took folic acid or not during their early pregnancy.

Results: The skeletal anomalies number was quite high between mothers having deficiency of folic acid and other vitamins (11% as compared to 2.4% of controls).

Conclusion: Pregnant mothers who have not taken folic acid and other vitamins throughout their early pregnancy developed cleft lip with associated skeletal anomalies in their offspring.