Histopathological Study of Uterine Leiomyoma in Hysterectomy Specimens at a Tertiary Care Hospital of Sindh

Abstract

Objective: Analyze histopathological changes within uterine leiomyomas in hysterectomy specimens and associated pathologies including variant uterine leiomyomas.

Study Design: Observational study.

Place and Duration of Study: This study was conducted at the Departments of Pathology and Gynecology/Obstetrics, Indus Medical College, Tando Muhammad Khan from July 2019 to February 2020.

Materials and Methods: Clinically diagnosed uterine leiomyomas hysterectomy specimens were subjected to gross and microscopic histopathological (H&E) examination with relevant clinical data. 337 specimens were examined during study period. Findings were noted in a pre – structured proforma. Data was analyzed on SPSS 21.0 (IBM, Incorporation, USA) at 95% CI (P≤ 0.05) and Microsoft Excel sheet.

Results: Mean age was 41.78±3.21 years. Age group 40 – 49.9 years comprised 54.89% of total cases. Intramural, sub –mucosal, sub – serosal and >1 location of leiomyoma was observed in 183 (54.3%), 65(19.2%), 71(21.0%) and 18 (5.3%) cases respectively. Leiomyoma variants of cellular type was noted in 13 (3.85%), epithelioid 5 (1.48%), symplastic 6(1.78%), neurilemma – like 3(0.89%), lipo – and angioleiomyoma in 1 (0.29%) each, dissecting leiomyoma in 2 (0.59%), hyaline globules 3 (0.89%) and mitotically active leiomyoma 1 (0.29%) respectively.

Conclusion: The present study reports majorities of leiomyomas were intramural (54.3%) and leiomyomas variants were found in 35 (10.38%) of specimen, thus making the histopathological examination mandatory.