Protective Effects of Phoenix Dactylifera on Monosodium Glutamate Induced Histomorphological Changes in Hepatocytes of Adult Male Albino Rats: A Light Microscopic Study

Abstract

Objective: To observe the possible protective role of Ajwa date fruit extract on monosodium glutamate induced histomorphological changes in liver of adult male rats.

Study Design: Experimental randomized controlled trial study

Place and Duration of Study: This study was conducted at the Department of Anatomy, Peshawar Medical College, Peshawar from July 2018 to December 2018.

Materials and Methods: This study was carried out on 24 adult male albino rats. The rats were randomly divided into 4 groups, A, B, C1 and C2, containing 06 rats in each group. Group A served as control. Group B received MSG 2g/kg/day prepared in distilled water; Group C1 was given MSG 2g/kg and ADFE 1g/kg and Group C2 was given MSG 2g/kg and ADFE 2g/kg by oral gavage once daily for 21 days. Rats were sacrificed on 22nd day. Liver from each rat was dissected out and examined microscopically.

Results: Histological examinations revealed, statistically highly significant (0.001) decrease in the number and increase in diameter of hepatocytes in toxic MSG group as compared to control group. These changes were protected in group C1 and C2, who received monosodium glutamate plus Ajwa date fruit extract.

Conclusion: Ajwa date fruit extract has protective effects on monosodium glutamate induced liver toxicity.