Comparison of Efficacy of 2% Clindamycin Vaginal Cream and Oral Metronidazole for Management of Bacterial Vaginosis in Non-Pregnant Females

Abstract

Objective: To compare the efficacy of 2% clindamycin vaginal cream and oral metronidazole for the management of bacterial vaginosis in non-pregnant females.

Study Design: Randomized controlled trial study.

Place and Duration of Study: This study was conducted at the Department of Obstetrics & Gynaecology, M. Islam Teaching Hospital Gujranwala from July 2019 to December 2019.

Materials and Methods: Two hundred cases were enrolled of age 20-40 years presented with clinically proven bacterial vaginosis. Patients were then divided randomly into two groups. Group A were given 2% clindamycin vaginal cream 5gm that was administered vaginally at bedtime for 3 days and group B was given metronidazole capsules 500 mg taken orally twice daily for 7 days and the efficacy was assessed after 1 week.

Results: The mean age in clindamycin group was 31.73±5.77 years and metronidazole group was 29.84±5.88 years. It was found that pH of vaginal fluid become <4.5 in 176 (88%) cases, amine test was negative in 174 (87%) cases and clue cells were absent in 181 (90.5%) cases. Efficacy was achieved in 171 (85.5%) cases, out of which 83 (83%) belonged to clindamycin group and 88 (88%) belonged to metronidazole group. The difference between both study groups was insignificant.

Conclusion: Three day course of clindamycin and 7-day course of metronidazole are equally effective.