Evaluation of Electrolytes and Renal Function in Patients with Hyperthyroidism in Mirpur AJK

Abstract

Objective: The objective of this study to evaluate electrolytes and renal function in patients with Hyperthyroidism in Mirpur AJK.

Study Design: Cross-sectional study

Place and Duration of Study: This study was conducted at the Department Physiology and Biochemistry Department of Mohtarma Benazir Bhutto Shaheed Medical College Mirpur AJK from January 2018 to July 2019.

Materials and Methods: We take for study 200 hyperthyroid patients’ and 100 health Control. Samples were centrifuged at 3000RPM for 10 min. T3, T4 and TSH were measured by Special Chemistry Analyze. Serum creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA) was analyzed by Micro lab 300 and used Merk Kits. Sodium (Na), Potassium (K), and Chloride were analyzed by Electrolyte Analyzer and used Merk Kits. Statistically analysis by SPSS version 20 software for ANOVA.

Results: Result showed that in hyperthyroid patients’ Uric acid (4.8±1.3) and Creatinine (0.5±0.4) mean concentration were lower as compared to control. The concentration of  urea were normal in hyperthyroid patients and control both while the concentration of eGFR  (203.2±103.8) was higher  in hyperthyroid patient as compare to control. The concentration of Sodium   (139.7±2.2) was higher in hyperthyroid patient as compare to control.

Conclusion: The present study demonstrated the hyperthyroidism are linked with alteration and changes of renal functions and also alter the electrolyte balance. Hormonal balance should be corrected properly