Association of Maternal Serum Vitamin D Level with Preeclampsia

Abstract

Objective: To determine the relationship between pre-eclampsia and maternal serum vitamin D levels.

Study Design: Case control Study

Place and Duration of Study: This study was conducted at the department of Obstetrics and Gynae Unit- 2, DUHS, OJHA, Karachi from 10^th December, 2021 to 10^th May, 2022.

Materials and Methods: This study was conducted on 162 pregnant patients between the age 18 to 35 years having singleton pregnancy greater than 20 weeks. Patients were divided in two groups, group A comprised of cases i.e. women with preeclampsia and group B were controls i.e. normotensive pregnant women. The relationship of maternal serum vitamin D was determined among cases and control groups. Patients with multiple gestations, fetal anomaly, diabetic and already taking vitamin D were excluded.

Results: This study was conducted on 162 patients divided in two groups, cases and controls. The mean age in group A was 26.65±4.71 years 27.10±5.73 years in group B. In group A 68 (84%) patients had vitamin D deficiency and in group B 45 (55.6%) patients had vitamin D deficiency. The association was statistically significant.

Conclusion: Our study concludes that there is a relationship between Vitamin D levels and preeclampsia. Vitamin D deficiency was found in 84% patients in case group and 55.6% in control group. The difference was significant statistically (P = 0.0001)