Frequency of Peptic Ulcer Disease in Patients with Chronic Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Abstract

Objective: To ascertain how often individuals on chronic nonsteroidal anti-inflammatory Drugs (NSAIDs) develop peptic ulcer disease.

Study Design: A Cross Sectional Study

Place and Duration of Study: This study was conducted at the Department of Gastroenterology, Qazi Hussain Ahmad Medical Complex Nowshera, from June 2022 to June 2023.

Methods: During the study period all patients with endoscopic findings of peptic ulcer and chronic use of NSAIDs were enrolled for the study. Age, gender, current indications for NSAIDs use, and period of NSAID use were noted. Patients were also assessed for other associated risk factors.

Results: During the study period 184 patients had peptic ulcers on endoscopy. In 15.8% (29/184) of individuals, peptic ulcers was caused by chronic NSAIDs use. Arthritis and malignancy related pain were the most common indications for chronic NSAIDs use and diclofenac was the most commonly used NSAIDs. H. pylori-infection was the most common associated risk factor (48%).

Conclusion: Our study showed the significant association of the chronic NSAIDs use and multiple other risk factors with the peptic ulcer disease. It emphasizes cautious use of NSAIDs in high risk patients, particularly who have multiple other risk factors.