Rational of Corticosteroid Nebulisation in Chronic Cough

Abstract

Objective: The objective of this study was to evaluate the effect of corticosteroid nebulization in patients with chronic cough, specifically assessing changes in cough severity, frequency, and quality of life.

Study Design: Prospective observational study.

Place and Duration of Study: This study was conducted at the Pediatrics Department Niazi Medical and Dental College Sargodha from August 2022 to March 2023.

Materials and Methods: A total of 175 patients with chronic cough were enrolled in the study. These patients were selected based on specific inclusion and exclusion criteria. Inclusion criteria included individuals aged 18 years or older, presenting with a chronic cough lasting for more than eight weeks despite appropriate treatment for underlying causes. Patients with significant comorbidities or contraindications to corticosteroid nebulization were excluded from the study.

Results: Following corticosteroid nebulization, there was a significant reduction in cough severity score (mean baseline: 7.2, mean post-treatment: 3.8, p < 0.001) and cough frequency (mean baseline: 25, mean post-treatment: 12, p < 0.001). The quality-of-life score showed a substantial increase (mean baseline: 45, mean post-treatment: 75, p < 0.001). Additionally, 82% of the patients reported satisfaction with the treatment.

Conclusion: Corticosteroid nebulization demonstrated a positive effect in chronic cough patients, as evidenced by reduced cough severity and frequency, improved quality of life, and high patient satisfaction rates. These findings support the use of corticosteroid nebulization as a potential treatment option for chronic cough. However, further research with larger sample sizes, control groups, and longer follow-up durations is warranted to validate these results and optimize treatment approaches.