Spirometric Reference Values in Healthy Non-Smoking Adults of Urban Population of Hyderabad Division

Abstract

Objective: To provide spirometric reference values in safe non-smoking adults from the Hyderabad division facilitate the pulmonologist and physicians to diagnose monitor and prognoses.

Study Design: Descriptive and cross-sectional study

Place and Duration of Study: This study was conducted at the Jamshoro University of Health and Medical Department for Physiology, Liaquat University from January, 2019 to December, 2019.

Materials and Methods: Respiratory system physical examination, blood pressure, height, weight, and BMI were noted. A proper protocol was applied for spirometry measurement using the Vitalograph alpha touch. The spirometric testing was performed in a standing position with nose clips applied on the volunteer`s nose using the manufacturer`s instructions. The Data was analyzed using SPSS version 16.0 for windows.

Results: A total of 450 subjects were included. Out of them 290(86.67%) were male, while 60 (13.33%) were female. The mean age SD of the sample group was 33±17.5 years. The male and female were of equal age and had the same Body Mass Index (BMI). (p = 0.9). An important variation was found between the expected and subject values (p0.05), while PIF was found to be significantly significant (p=0.001). Age was shown to have a strong negative association with FVC (r=-0.28, p=0.0001), FEV1 (r=-0.309, p=0.0001), FEV1/FVC x100 (r=-0.28, p=0.84), FEV6 (r=-0.141, p=0.003), FIVC (r=-0.97, p=0.04), and PIF (r=-0.157, p=0.001). Except for FEV1R (r=0.03, p=0.53), PEF (L/s) (r=0.016, p=0.78), and PEF (L/min) (r=0.016, p=0.74), all spirometry parameters were positively correlated with height for both male and female. FVC (r=0.94, p=0.0001), FEV1 (r=0.51, p=0.0001), and (r=0.54, p=0.0001) were all positively correlated with height (r=0.54, p=0.0001).

Conclusion: The results of pulmonary function test values are comparable to studies reported from Pakistani and south East Asia. The prediction equation obtained may be utilized as reference values for pulmonary function testing for the population of Hyderabad Division.