Pre-Eclampsia and Pregnancy Outcome: A Population Based Case Control Study in Karachi Pakistan

Abstract

Objective: To determine the pregnancy outcomes in women presented with severe pre-eclampsia in Karachi Pakistan.

Study Design: Case control/Prospective study.

Place and Duration of Study: This study was conducted at the Medicare Cardiac & General Hospital Karachi during from July 2016 to June 2018.

Materials and Methods: One hundred and ten patients with ages 18 to 45 years presented with pre-eclampsia were included in this study. Patients detailed demographic including age, parity, gestational age, and body mass index were recorded after taking written consent. Patients complete blood picture was examined. Complications associated with preeclampsia were examined.

Results: Twenty-two (20%) were ages <20 years, 48 (43.64%) were ages 20 to 30 years, 36 (32.72%) were ages 31 to 40 years and 4 (3.64%) were ages above 40 years. 42 (38.18%) were prim gravida while 68 (61.82%) were multigravida. Mean gestational age was 33.45±4.68 weeks. HELLP syndrome found in 20 (18.18%) patients, 10 (9.09%) patients had eclampsia, and 14 (14.55%) patients had placental abruption, coagulopathy found in 3 (2.73%) patients, 2 (1.82%) patients developed acute renal failure and 2 (1.82%) patients were died.

Conclusion: Pre-eclampsia is highly associated with major maternal complications such as HELLP syndrome, eclampsia, placental abruption and maternal mortality.