Comparison of Effectiveness of Oral Fluconazole and Intralesional Glucantime in the Treatment of Cutaneous Leishmaniasis

Abstract

Objective: To Assess the Effectiveness of Oral Fluconazole and Intralesional Glucantime in the treatment of Cutaneous Leishmaniasis.

Study Design: Randomized Control Trial study

Place and Duration of Study: This study was conducted at the Dermatology Department, PIMS Islamabad from April 2014 till November 2014.

Materials and Methods: The study was composed of 240 patients and they were equally divided into two groups by lottery method. In Group A, 120 patients were given oral Fluconazole daily for 6 weeks while in Group B, 120 patients were given intralesional Glucantime for 21 to 28 days. All the data was recorded on a structured proforma. Chi square test was used to compare efficacy between the two groups.

Results: In Group A, 99 patients showed complete resolution of the lesions while 21 showed no resolution after treatment with oral Fluconazole for 6 weeks. In Group B, 109 patients showed complete resolution while 11 showed no resolution with intralesional Glucantime. The difference between the groups was significant with p value of less than 0.05.

Conclusion: Intralesional Glucantime is significantly more effective than oral Fluconazole in the treatment of Cutaneous Leishmaniasis.