Frequency of Acute Kidney Injury Among Septic Children, Admitted at a Tertiary Care Hospital

Abstract

Objective: The objective of our study was to determine the frequency of acute kidney injury (AKI) among septic patients admitted at a tertiary care hospital.

Study Design: Descriptive / observational study

Place and Duration of Study: This study was conducted at a Tertiary Care Hospital of Karachi from  1^st July 2015 to 31^st December 2015.

Materials and Methods: Total 237 patients who were diagnosed as having sepsis with age 1 to 144 months were included in the study. These patients were monitored till the development of acute kidney injury (AKI).

The frequency and percentages were calculated for qualitative variables i.e. gender, and age group, while mean and standard deviation was calculated for quantitative variables i.e., age, baseline serum creatinine, maximum serum creatinine and hospital stay. P-value ≤0.05 was considered as significant.

Results: Total 237 patients were included in study with age 1 to 144 months 61.93(±33.510). Out of 237 patients 62 i.e. (26.2%) developed Acute Kidney Injury (AKI). A significant association of acute kidney injury was observed with hospital stay (p<0.001) and male gender (p=0.045). No significant association of acute kidney injury was observed with age (p=0.737) and baseline serum creatinine (p=0.104).

Conclusion: Development of Acute kidney injury is common in septic children and is significantly associated with increased hospital stay. This study provides statistics of sepsis induced AKI in the local population. In addition, the results emphasize on early identification of AKI among septic children to prevent further morbidity and mortality.